October 24, 2017, 5:45 pm
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1 Philippine Peso = 0.07134 UAE Dirham
1 Philippine Peso = 2.20455 Albanian Lek
1 Philippine Peso = 0.03458 Neth Antilles Guilder
1 Philippine Peso = 0.33662 Argentine Peso
1 Philippine Peso = 0.02487 Australian Dollar
1 Philippine Peso = 0.03458 Aruba Florin
1 Philippine Peso = 0.03885 Barbados Dollar
1 Philippine Peso = 1.60625 Bangladesh Taka
1 Philippine Peso = 0.03236 Bulgarian Lev
1 Philippine Peso = 0.00733 Bahraini Dinar
1 Philippine Peso = 33.77953 Burundi Franc
1 Philippine Peso = 0.01943 Bermuda Dollar
1 Philippine Peso = 0.02645 Brunei Dollar
1 Philippine Peso = 0.13326 Bolivian Boliviano
1 Philippine Peso = 0.06247 Brazilian Real
1 Philippine Peso = 0.01943 Bahamian Dollar
1 Philippine Peso = 1.26263 Bhutan Ngultrum
1 Philippine Peso = 0.2012 Botswana Pula
1 Philippine Peso = 388.88889 Belarus Ruble
1 Philippine Peso = 0.03881 Belize Dollar
1 Philippine Peso = 0.02456 Canadian Dollar
1 Philippine Peso = 0.01915 Swiss Franc
1 Philippine Peso = 12.27409 Chilean Peso
1 Philippine Peso = 0.12894 Chinese Yuan
1 Philippine Peso = 57.24748 Colombian Peso
1 Philippine Peso = 10.99748 Costa Rica Colon
1 Philippine Peso = 0.01943 Cuban Peso
1 Philippine Peso = 1.82304 Cape Verde Escudo
1 Philippine Peso = 0.42383 Czech Koruna
1 Philippine Peso = 3.43493 Djibouti Franc
1 Philippine Peso = 0.12305 Danish Krone
1 Philippine Peso = 0.91725 Dominican Peso
1 Philippine Peso = 2.22277 Algerian Dinar
1 Philippine Peso = 0.25859 Estonian Kroon
1 Philippine Peso = 0.34188 Egyptian Pound
1 Philippine Peso = 0.52409 Ethiopian Birr
1 Philippine Peso = 0.01653 Euro
1 Philippine Peso = 0.03972 Fiji Dollar
1 Philippine Peso = 0.01475 Falkland Islands Pound
1 Philippine Peso = 0.01472 British Pound
1 Philippine Peso = 0.08496 Ghanaian Cedi
1 Philippine Peso = 0.91414 Gambian Dalasi
1 Philippine Peso = 174.78632 Guinea Franc
1 Philippine Peso = 0.14265 Guatemala Quetzal
1 Philippine Peso = 3.93765 Guyana Dollar
1 Philippine Peso = 0.15157 Hong Kong Dollar
1 Philippine Peso = 0.45491 Honduras Lempira
1 Philippine Peso = 0.12399 Croatian Kuna
1 Philippine Peso = 1.18939 Haiti Gourde
1 Philippine Peso = 5.08741 Hungarian Forint
1 Philippine Peso = 263.01476 Indonesian Rupiah
1 Philippine Peso = 0.06781 Israeli Shekel
1 Philippine Peso = 1.26296 Indian Rupee
1 Philippine Peso = 22.669 Iraqi Dinar
1 Philippine Peso = 667.07459 Iran Rial
1 Philippine Peso = 2.04662 Iceland Krona
1 Philippine Peso = 2.45552 Jamaican Dollar
1 Philippine Peso = 0.01374 Jordanian Dinar
1 Philippine Peso = 2.20812 Japanese Yen
1 Philippine Peso = 2.00952 Kenyan Shilling
1 Philippine Peso = 1.32896 Kyrgyzstan Som
1 Philippine Peso = 78.1857 Cambodia Riel
1 Philippine Peso = 8.06566 Comoros Franc
1 Philippine Peso = 17.48252 North Korean Won
1 Philippine Peso = 21.95047 Korean Won
1 Philippine Peso = 0.00587 Kuwaiti Dinar
1 Philippine Peso = 0.01593 Cayman Islands Dollar
1 Philippine Peso = 6.52234 Kazakhstan Tenge
1 Philippine Peso = 161.26651 Lao Kip
1 Philippine Peso = 29.24437 Lebanese Pound
1 Philippine Peso = 2.98368 Sri Lanka Rupee
1 Philippine Peso = 2.29817 Liberian Dollar
1 Philippine Peso = 0.267 Lesotho Loti
1 Philippine Peso = 0.05922 Lithuanian Lita
1 Philippine Peso = 0.01205 Latvian Lat
1 Philippine Peso = 0.02654 Libyan Dinar
1 Philippine Peso = 0.18329 Moroccan Dirham
1 Philippine Peso = 0.33557 Moldovan Leu
1 Philippine Peso = 1.00952 Macedonian Denar
1 Philippine Peso = 26.41803 Myanmar Kyat
1 Philippine Peso = 47.5136 Mongolian Tugrik
1 Philippine Peso = 0.15611 Macau Pataca
1 Philippine Peso = 6.8244 Mauritania Ougulya
1 Philippine Peso = 0.65657 Mauritius Rupee
1 Philippine Peso = 0.30245 Maldives Rufiyaa
1 Philippine Peso = 13.91123 Malawi Kwacha
1 Philippine Peso = 0.37068 Mexican Peso
1 Philippine Peso = 0.08228 Malaysian Ringgit
1 Philippine Peso = 0.26663 Namibian Dollar
1 Philippine Peso = 6.91531 Nigerian Naira
1 Philippine Peso = 0.59261 Nicaragua Cordoba
1 Philippine Peso = 0.15522 Norwegian Krone
1 Philippine Peso = 2.01146 Nepalese Rupee
1 Philippine Peso = 0.02786 New Zealand Dollar
1 Philippine Peso = 0.00746 Omani Rial
1 Philippine Peso = 0.01943 Panama Balboa
1 Philippine Peso = 0.06287 Peruvian Nuevo Sol
1 Philippine Peso = 0.06211 Papua New Guinea Kina
1 Philippine Peso = 1 Philippine Peso
1 Philippine Peso = 2.04157 Pakistani Rupee
1 Philippine Peso = 0.0698 Polish Zloty
1 Philippine Peso = 109.32012 Paraguayan Guarani
1 Philippine Peso = 0.07303 Qatar Rial
1 Philippine Peso = 0.07595 Romanian New Leu
1 Philippine Peso = 1.11692 Russian Rouble
1 Philippine Peso = 16.13209 Rwanda Franc
1 Philippine Peso = 0.07284 Saudi Arabian Riyal
1 Philippine Peso = 0.15112 Solomon Islands Dollar
1 Philippine Peso = 0.25618 Seychelles Rupee
1 Philippine Peso = 0.12937 Sudanese Pound
1 Philippine Peso = 0.15921 Swedish Krona
1 Philippine Peso = 0.02646 Singapore Dollar
1 Philippine Peso = 0.01475 St Helena Pound
1 Philippine Peso = 0.43135 Slovak Koruna
1 Philippine Peso = 148.01865 Sierra Leone Leone
1 Philippine Peso = 10.85859 Somali Shilling
1 Philippine Peso = 405.06606 Sao Tome Dobra
1 Philippine Peso = 0.16997 El Salvador Colon
1 Philippine Peso = 10.0035 Syrian Pound
1 Philippine Peso = 0.26663 Swaziland Lilageni
1 Philippine Peso = 0.64433 Thai Baht
1 Philippine Peso = 0.04839 Tunisian Dinar
1 Philippine Peso = 0.04297 Tongan paʻanga
1 Philippine Peso = 0.07213 Turkish Lira
1 Philippine Peso = 0.12972 Trinidad Tobago Dollar
1 Philippine Peso = 0.58747 Taiwan Dollar
1 Philippine Peso = 43.47319 Tanzanian Shilling
1 Philippine Peso = 0.51593 Ukraine Hryvnia
1 Philippine Peso = 70.94017 Ugandan Shilling
1 Philippine Peso = 0.01943 United States Dollar
1 Philippine Peso = 0.57556 Uruguayan New Peso
1 Philippine Peso = 156.17716 Uzbekistan Sum
1 Philippine Peso = 0.19376 Venezuelan Bolivar
1 Philippine Peso = 441.37529 Vietnam Dong
1 Philippine Peso = 2.06876 Vanuatu Vatu
1 Philippine Peso = 0.04978 Samoa Tala
1 Philippine Peso = 10.83178 CFA Franc (BEAC)
1 Philippine Peso = 0.05245 East Caribbean Dollar
1 Philippine Peso = 10.68376 CFA Franc (BCEAO)
1 Philippine Peso = 1.97222 Pacific Franc
1 Philippine Peso = 4.85431 Yemen Riyal
1 Philippine Peso = 0.26674 South African Rand
1 Philippine Peso = 100.80614 Zambian Kwacha
1 Philippine Peso = 7.02991 Zimbabwe dollar

The truth about Metformin

ONE of the most popular and very useful medications today worldwide is Metformin (Glucophage). This drug, whose molecular formula, C4H11N5, was first synthesized in 1929 and clinically introducedin the late 1950s by Jean Sterne, a French physician, who named it Glucophage, meaning glucose eater. In the United States, this drug was approved for type 2 diabetesby the FDA in 1994 and was marketed as Glucophage on March 3, 1995.

Evidence based clinical practice of today uses Metformin as the first-line oral drug for the treatment of type 2 diabetes mellitus, especially those who are overweight, according to the American Diabetes Association and the American College of Physicians.

In spite of its widespread global use and hundreds of millions benefiting from it, there are misleading and egregious assertions by some manufacturers of alternative herbal preparations for diabetes that Metformin is useless and dangerous. These are irresponsible claims in order for the uninformed and the gullible individuals to buy and use their products instead. These products, which have not been studied by the food and drug administration of the United States, the Philippines, or other countries, could be untested, unrefined, adulterated, contaminated, and are unsafe and possibly toxic in the long run.

How does Metformin work?

Contrary to some understanding, Metformin does not directly lower blood sugar like insulin does. Metformin acts to reduce the insulin resistance of the body cells to allow our own natural insulinto enter the cells to enable normal sugar metabolism. A significant number of type 2 diabetes suffer from insulin resistance that prevents insulin from entering the cells and doing its normal job, so the blood sugar goes up. Metformin reduces the resistance and improves the sensitivity of our body tissues in order for insulin to work more effectively. It also lowers the production of blood sugar in the liver. Again, on its own, Metformin does not cause hypoglycemia (low blood sugar).

Are ampalaya preparations as effective?

No. Ampalaya (bitter melon), a vegetable-fruit dish commonly prepared in Asian countries, has been found to lower blood sugar level a little, not significantly enough to be effective in controlling blood sugar level among diabetics. In spite of this limitation and lack of efficacy, ampalya preparations (pills, potions, lotions, teas) are on the shelves of many stores, claiming to lower blood sugar level, aimed at scamming the ignorant and gullible public. This is fraudulent because there have been reports of diabetics who stopped their prescribed medications and took these ampalaya preparations instead and have gone into diabetic comma. While eating ampalaya, a succulent dish, is a good idea for everyone, especially for diabetics, the use of the ampalaya preparations on the market as a substitute for (instead of) the prescription medication for diabetes is very dangerous and could be fatal.

What are the other uses of Metformin?

An amazing versatile drug, Metformin is also used for the treatment of polycystic ovary syndrome, and there are some limited suggestions that it may prevent cardiovascular disease and cancer complications of diabetes. More clinical studies are needed to confirm these. Its use is not linked to weight gain and higher risk of low blood sugar in contrast to the use of sulfonylureas for diabetes. Metformin also modestly reduces LDL (bad cholesterol) and triglycerides. Among obese non-diabetics, Metformin has been observed to be induce some weight loss. There is also a study that suggests Metformin be used as a second-line drug if clomifene treatment fails in the management of infertility among women.

Can Metformin prevent diabetes?

Among those with pre-diabetes, who are at risk of developing full-blown type 2 diabetes, treatment with Metformin has been found to reduce the chances of developing this metabolic disease. The same may be achieved with intensive regimented physical exercise done religiously, at least 20 minutes 5 days a week, as shown by the US Diabetes Prevention Program of lifestyle modification. This non-medication, exercise strategy, could lower the incidence of diabetes by 58 percent. Medical research on this continues to confirm these findings.

Does Metformin improve longevity?

This wonderful drug appears to increase longevity, at least in mice in the experimental laboratory, by a mean life span of 37.8 percent. Findings like this are extrapolated to be applicable among humans. There is scientific evidence that hyperglycemia (high blood sugar) and hyperinsulinemia (high insulin levels) are significant factors both in aging and development of cancer. The life prolonging effects of dieting (caloric restriction) has been attributed to decreasing IGF-1 (insulin growth factor-1), so eating less than maximal will reduce the need for the body to secrete more insulin and its level would go down, including body weight, and eventually in the long run slowing down aging and cancer risk. As my late teacher, Dr. Fe del Mundo, an internationally renowned pediatrician-scientist who lived to almost 100, still treating patients at age 94, stated, her secret to longevity was to push herself “away from the dining table less than full.”

What are the side-effects of Metformin?

Metformin is well-tolerated by most. Mild diarrhea is the usual initial side-effect that is transient, which stops after a day or so. Nausea, abdominal pains, flatulence have been reported but they are mild and temporary. If taken in overly large doses, it causes high blood lactic acid level. This drug is contraindicated among those with kidney or liver disease. Long term use of Metformin leads to vitamin B-12 deficiency, and increase the homocysteine level, which increases the risk for hardening of the arteries. Vitamin B-6, B-12, and Folic Acidmight be considered by the attending physician for these. Among pregnant women with gestational diabetes, insulin is the preferred treatment, although there is no clear evidence that Metformin causes harm among these patients. If the side-effects continue for days, which is not common, a medical consultation is advised.

Is it safe to self-medicate with Metformin?

As a rule, it is never safe to self-medicate or share medications with anyone, even with over-the-counter drugs, unless prescribed by a physician. Allergy and unexpected untoward reactions, side-effects, and unforeseen complication, sometimes fatal, can occur in some individuals. Metformin and all other medications must be taken under the guidance of a physician, who knows your personal circumstances and health.

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Column of the Day

Thank You, Mr. President

By REY O. ARCILLA | October 24,2017
‘f nobody else would do it and if only to give credit where credit is due, I would like to thank and congratulate President Duterte for a job well done.’

Opinion of the Day

APEC Vietnam, Asean Manila

By ABIGAIL VALTE | October 24, 2017
‘Hopefully our representatives take full advantage of these opportunities to push our agenda forward.’